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DULOXETINE IN THE
TREATMENT OF STRESS URINARY INCONTINENCE
Kristie L
Osborne and Steven M Davis
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OBJECTIVE: To review the available literature regarding the use of duloxetine in the treatment of stress urinary incontinence.
DATA SOURCES: Clinical trials were obtained through a PubMed search (1966–December 2004) with the key words duloxetine, urinary incontinence, and stress.
DATA SYNTHESIS: This article analyzes 5 clinical studies comparing duloxetine with placebo. The randomized, double-blind, multicenter trials were performed in the US and throughout the world and had strict inclusion criteria to enroll only patients with confirmed stess urinary incontinence. All trials showed a statistically significant decrease in incontinence episode frequency of 50-60% for duloxetine compared with a placebo response of 27-40%.
CONCLUSIONS: Duloxetine appears to be an effective treatment for stress urinary incontinence. Additional trials comparing duloxetine with pelvic floor muscle training would better define duloxetine's place in therapy.
J Pharm Technol 2005;21:337-40.
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